Dr. Günther Ross
Head of Chemistry

Günther Ross was born 1969 in Freising, Germany and studied chemistry at the Technical University of Munich. He specialized in organic chemistry and earned his PhD in the group of Prof. Ivar Ugi with a thesis about the stereoselective Ugi four component reaction. He gained experience in medicinal chemistry as a postdoctoral research associate in the group of Prof. Robert Lightowlers and Prof. Douglass Turnbull at the Medical School of the University of Newcastle upon Tyne, UK, where he worked on the development of antigenomic agents for mitochondrial gene therapy. Günther Ross joined Priaton in 2003 and was appointed Head of Chemistry in 2004.

List of publications

Goebel, M.; Nothofer, H.-G.; Roß, G.; Ugi, I.: A facile synthesis of per-O-alkylated glycono-d-lactones from per-O-alkylated glycopyranosides and a novel ring contraction for pyranoses. Tetrahedron 1997, 53, 3123.

Ross, G.; Ugi, I.: Stereoselective syntheses of a-amino acid and peptide derivatives by the U-4CR of 5-desoxy-5-thio-D-xylopyranosylamine. Can. J. Chem. 2001, 79(12), 1934.

Ross, G. F.; Herdtweck, E.; Ugi, I.: Stereoselective U-4CRs with 1-amino-5-desoxy-5-thio-2,3,4-O-isobutanoyl-b-D-xylopyranose – an effective and selectively removable chiral auxiliary. Tetrahedron 2002, 58, 6127.

Ugi, I.; Roß, G.; Burdack, C.: The chemical progress of multicomponent reactions. In Geckeler, K. E. (Ed.): Advanced macromolecular and supramolecular materials and processes. Kluwer Academic / Plenum Publishers 2003.

McGregor, A.; Smith P. M.; Ross G. F.; Taylor R. W.; Turnbull D. M.; Lightowlers R. N.: Bridging PNAs can bind preferentially to a deleted mitochondrial DNA template but replication by mitochondrial DNA polymerase g in vitro is not impaired. Biochim. Biophys. Acta 2003, 1629(1-3), 73.

Ross, G. F.; Smith, P. M.; McGregor, A.; Turnbull, D. M.; Lightowlers, R. N.: Synthesis of trifunctional PNA-benzophenone derivatives for mitochondrial targeting, selective DNA binding, and photo-cross-linking. Bioconjug. Chem. 2003, 14(5), 962.

Smith, P. M.; Ross, G. F.; Wardell, T. M.; Taylor, R. W.; Turnbull, D. M.; Lightowlers, R. N.: The use of PNAs and their derivatives in mitochondrial gene therapy. In Janson, C. und During, M. (Eds.): Peptide nucleic acids, morpholinos, and related antisense biomolecules. Landes Bioscience 2004.

Smith, P. M.; Ross, G. F.; Taylor, R. W.; Turnbull, D. M.; Lightowlers, R. N.: Strategies for treating disorders of the mitochondrial genome. Biochim. Biophys. Acta. 2004, 1659(2-3), 232.

Umkehrer, M.; Kolb, J.; Burdack, C.; Ross, G.; Hiller, W.: Synthesis of tetrazolopiperazine building blocks by a novel multi-component reaction. Tetrahedron Lett. 2004, 45, 6421.

Mayer, J., Umkehrer, M., Kalinski, C., Ross, G., Kolb, J., Burdack C., Hiller, W.: New cleavable isocyanides for the combinatorial synthesis of a-amino acid analogue tetrazoles, Tetrahedron Lett. 2005, 46, 7393.

Kalinski, C.; Umkehrer, M.; Gonnard, S.; Jäger, N.; Ross, G.; Hiller, W.: A new and versatile Ugi/S_NAr synthesis of fused 4,5-dihydrotetrazolo[1,5-a]quinoxalines. Tetrahedron Lett. 2006, 47, 2041.

Kalinski, C.; Umkehrer, M.; Ross, G.; Kolb, J.; Burdack, C; Hiller, W.: Highly substituted indol-2-ones, quinoxalin-2-ones and benzodiazepin-2,5-diones via a new Ugi(4CR)-Pd assisted N-aryl amidation strategy. Tetrahedron Lett. 2006, 47, 3423.

Kalinski, C.; Umkehrer, M.; Schmidt, J.; Ross, G.; Kolb, J.; Burdack, C; Hiller, W.; Hoffmann, S.: A novel one-pot synthesis of highly diverse indole scaffolds by the Ugi/Heck reaction. Tetrahedron Lett. 2006, 47, 4683.